| Post Translational Modifications | Tyrosine-phosphorylated upon stimulation of cells with EGF. May undergo proteolytic cleavage to give peptides which reassemble to form a transporter complex. |
| Function | Multifunctional protein that functions as a downstream effector of RALA and RALB. As a GTPase-activating protein/GAP can inactivate CDC42 and RAC1 by stimulating their GTPase activity. As part of the Ral signaling pathway, may also regulate ligand-dependent EGF and insulin receptors-mediated endocytosis. During mitosis, may act as a scaffold protein in the phosphorylation of EPSIN/EPN1 by the mitotic kinase cyclin B-CDK1, preventing endocytosis during that phase of the cell cycle. During mitosis, also controls mitochondrial fission as an effector of RALA. Recruited to mitochondrion by RALA, acts as a scaffold to foster the mitotic kinase cyclin B-CDK1-mediated phosphorylation and activation of DNM1L. Could also function as a primary ATP-dependent active transporter for glutathione conjugates of electrophiles. May also actively catalyze the efflux of a wide range of substrates including xenobiotics like doxorubicin (DOX) contributing to cell multidrug resistance. |
| Protein Name | Rala-Binding Protein 1Ralbp176 Kda Ral-Interacting ProteinDinitrophenyl S-Glutathione AtpaseDnp-Sg AtpaseRal-Interacting Protein 1 |
| Database Links | Reactome: R-HSA-9013148Reactome: R-HSA-9013149 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmCytosolCytoskeletonSpindle PoleNucleusMitochondrionCytosolic Protein That Transiently Associates With The Mitotic Spindle Poles In Early ProphaseAnd Dissociates From Them After Completion Of MitosisTargeted To The Plasma Membrane Through Its Interaction With RalbDirected By Fgf SignalingDocking On The Membrane Is Required To Transduce The Ral SignalRecruited By Rala To The Mitochondrion During Mitosis Where It Regulates Mitochondrial FissionNuclear Localization Is Cell Cycle Dependent While Membrane Localization Is Seen In Adherent CellsThe Region Involved In Membrane Association Could Form Transmembrane Domains And Expose A Part Of The Protein Extracellularly (Probable) |
| Alternative Protein Names | Rala-Binding Protein 1 proteinRalbp1 protein76 Kda Ral-Interacting Protein proteinDinitrophenyl S-Glutathione Atpase proteinDnp-Sg Atpase proteinRal-Interacting Protein 1 proteinRALBP1 proteinRLIP proteinRLIP1 proteinRLIP76 protein |
Information sourced from Uniprot.org
