Human RAD51B protein (Recombinant) (His-Tag) (STJP018565)
SPECIFICATIONS
HostE.coli
ImmunogenHuman
General Information
| Short Description | Recombinant-Human RAD51B-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Applications | SDS-PAGE/Denatured |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Concentration | 0.5 mg/mL |
| Formulation | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing, 10% Glycerol, 0.4M urea |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | RAD51B |
| Gene ID | 5890 |
| Uniprot ID | RA51B_HUMAN |
| Accession Number | NP_002868 |
| Immunogen | Human |
| Immunogen Region | 1-350aa |
| Immunogen Sequence |
Additional Info
| Tissue Specificity | Expressed in a wide range of tissues. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by BCR-ABL. |
| Function | Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. |
| Protein Name | Dna Repair Protein Rad51 Homolog 2R51h2Rad51 Homolog BRad51bRad51-Like Protein 1 |
| Database Links | Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693616Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709603Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Dna Repair Protein Rad51 Homolog 2 proteinR51h2 proteinRad51 Homolog B proteinRad51b proteinRad51-Like Protein 1 proteinRAD51B proteinRAD51L1 proteinREC2 protein |
Information sourced from Uniprot.org