| Post Translational Modifications | Ubiquitinated by the SCF(FBH1) E3 ubiquitin ligase complex, regulating RAD51 subcellular location and preventing its association with DNA. Ubiquitinated by RFWD3 in response to DNA damage: ubiquitination leads to degradation by the proteasome, promoting homologous recombination. Phosphorylation of Thr-309 by CHEK1 may enhance association with chromatin at sites of DNA damage and promote DNA repair by homologous recombination. Phosphorylated at Ser-14 by PLK1, triggering phosphorylation at Thr-13 by CK2, thereby promoting interaction with TOPBP1 and recruitment to DNA damage sites during S-phase. Phosphorylation by ABL1 inhibits function. |
| Function | Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Part of a PALB2-scaffolded HR complex containing BRCA2 and RAD51C and which is thought to play a role in DNA repair by HR. Plays a role in regulating mitochondrial DNA copy number under conditions of oxidative stress in the presence of RAD51C and XRCC3. Also involved in interstrand cross-link repair. |
| Protein Name | Dna Repair Protein Rad51 Homolog 1Hsrad51Hrad51Rad51 Homolog A |
| Database Links | Reactome: R-HSA-5685938Reactome: R-HSA-5685942Reactome: R-HSA-5693554Reactome: R-HSA-5693568Reactome: R-HSA-5693579Reactome: R-HSA-5693616Reactome: R-HSA-8953750Reactome: R-HSA-912446Reactome: R-HSA-9701192Reactome: R-HSA-9704331Reactome: R-HSA-9704646Reactome: R-HSA-9709570Reactome: R-HSA-9709603 |
| Cellular Localisation | NucleusCytoplasmPerinuclear RegionMitochondrion MatrixChromosomeCytoskeletonMicrotubule Organizing CenterCentrosomeColocalizes With Rad51ap1 And Rpa2 To Multiple Nuclear Foci Upon Induction Of Dna DamageDna Damage Induces An Increase In Nuclear LevelsTogether With Fignl1Redistributed In Discrete Nuclear Dna Damage-Induced Foci After Ionizing Radiation (Ir) Or Camptothecin (Cpt) TreatmentAccumulated At Sites Of Dna Damage In A Spidr-Dependent MannerRecruited At Sites Of Dna Damage In A Mcm9-Mcm8-Dependent MannerRecruited At Sites Of Dna Damage Following Interaction With Topbp1 In S-PhaseColocalizes With Ercc5/Xpg To Nuclear Foci In S PhaseRecruited To Stalled Replication Forks During Replication Stress By The Tonsl-Mms22l ComplexAs Well As Atad5 And Wdr48 In An Atr-Dependent Manner |
| Alternative Protein Names | Dna Repair Protein Rad51 Homolog 1 proteinHsrad51 proteinHrad51 proteinRad51 Homolog A proteinRAD51 proteinRAD51A proteinRECA protein |
Information sourced from Uniprot.org
