| Post Translational Modifications | Cleaved by separase/ESPL1 at the onset of anaphase.this cleavage is required for sister chromatid separation and cytokinesis. Cleaved by caspase-3/CASP3 or caspase-7/CASP7 at the beginning of apoptosis. Phosphorylated.becomes hyperphosphorylated in M phase of cell cycle. The large dissociation of cohesin from chromosome arms during prophase may be partly due to its phosphorylation by PLK1. |
| Function | Double-strand-break repair protein rad21 homolog: As a member of the cohesin complex, involved in sister chromatid cohesion from the time of DNA replication in S phase to their segregation in mitosis, a function that is essential for proper chromosome segregation, post-replicative DNA repair, and the prevention of inappropriate recombination between repetitive regions. The cohesin complex may also play a role in spindle pole assembly during mitosis. In interphase, cohesins may function in the control of gene expression by binding to numerous sites within the genome. May control RUNX1 gene expression (Probable). Binds to and represses APOB gene promoter. May play a role in embryonic gut development, possibly through the regulation of enteric neuron development. 64-kDa C-terminal product: May promote apoptosis. |
| Protein Name | Double-Strand-Break Repair Protein Rad21 HomologHhr21Nuclear Matrix Protein 1Nxp-1Scc1 Homolog Cleaved Into - 64-Kda C-Terminal Product64-Kda Carboxy-Terminal Product65-Kda Carboxy-Terminal Product |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-2467813Reactome: R-HSA-2468052Reactome: R-HSA-2470946Reactome: R-HSA-2500257Reactome: R-HSA-3108214Reactome: R-HSA-9018519 |
| Cellular Localisation | Double-Strand-Break Repair Protein Rad21 Homolog: NucleusNucleus MatrixChromosomeCentromereCytoplasmCytoskeletonSpindle PoleAssociates With ChromatinBefore ProphaseScattered Along Chromosome ArmsDuring Prophase And PrometaphaseMost Cohesins Dissociate From The Arms Of Condensing ChromosomePossibly Through Plk1-Mediated PhosphorylationA Small Amount Of Cohesin Remains In Centromeric Regions And Is Removed From Chromosomes Only At The Onset Of AnaphaseAt AnaphaseCleavage By Separase/Espl1 Leads To The Dissociation Of Cohesin From Chromosomes And Chromosome Separation64-Kda C-Terminal Product: CytoplasmCytosolNucleus |
| Alternative Protein Names | Double-Strand-Break Repair Protein Rad21 Homolog proteinHhr21 proteinNuclear Matrix Protein 1 proteinNxp-1 proteinScc1 Homolog Cleaved Into - 64-Kda C-Terminal Product protein64-Kda Carboxy-Terminal Product protein65-Kda Carboxy-Terminal Product proteinRAD21 proteinHR21 proteinKIAA0078 proteinNXP1 proteinSCC1 protein |
Information sourced from Uniprot.org
