| Host: | E. coli |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human RAC2-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | RAC2 |
| Gene ID: | 5880 |
| Uniprot ID: | RAC2_HUMAN |
| Immunogen Region: | Met1-Leu192 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase. |
| Protein Name | Ras-Related C3 Botulinum Toxin Substrate 2GxSmall G ProteinP21-Rac2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1222556Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-4086400Reactome: R-HSA-5668599Reactome: R-HSA-6811558Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmMembrane-Associated When Activated |
| Alternative Protein Names | Ras-Related C3 Botulinum Toxin Substrate 2 proteinGx proteinSmall G Protein proteinP21-Rac2 proteinRAC2 protein |
Information sourced from Uniprot.org
