| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human RAC2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol 2mM EDTA, 2mM DTT, 0.1 M NaCl. |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | RAC2 |
| Gene ID: | 5880 |
| Uniprot ID: | RAC2_HUMAN |
| Immunogen Region: | 1-189aa |
| Accession Number: | NP_002863 |
| Immunogen: | Human |
| Immunogen Sequence: | MGSSHHHHHH SSGLVPRGSH MQAIKCVVVG DGAVGKTCLL ISYTTNAFPG EYIPTVFDNY SANVMVDSKP VNLGLWDTAG QEDYDRLRPL SYPQTDVFLI CFSLVSPASY ENVRAKWFPE VRHHCPSTPI ILVGTKLDLR DDKDTIEKLK EKKLAPITYP QGLALAKEID SVKYLECSAL TQRGLKTVFD EAIRAVLCPQ PTRQQKRAC |
| Tissue Specificity | Hematopoietic specific. |
| Post Translational Modifications | (Microbial infection) Glycosylated at Tyr-32 by Photorhabdus asymbiotica toxin PAU_02230. Mono-O-GlcNAcylation by PAU_02230 inhibits downstream signaling by an impaired interaction with diverse regulator and effector proteins of Rac and leads to actin disassembly. |
| Function | Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In its active state, binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Regulatory subunit of the phagocyte NADPH oxidase complex that mediates the transfer of electrons from cytosolic NADPH to O2 to produce the superoxide anion (O2(-)). |
| Protein Name | Ras-Related C3 Botulinum Toxin Substrate 2GxSmall G ProteinP21-Rac2 |
| Database Links | Reactome: R-HSA-114604Reactome: R-HSA-1222556Reactome: R-HSA-1257604Reactome: R-HSA-2219530Reactome: R-HSA-4086400Reactome: R-HSA-5668599Reactome: R-HSA-6811558Reactome: R-HSA-9013404 |
| Cellular Localisation | CytoplasmMembrane-Associated When Activated |
| Alternative Protein Names | Ras-Related C3 Botulinum Toxin Substrate 2 proteinGx proteinSmall G Protein proteinP21-Rac2 proteinRAC2 protein |
Information sourced from Uniprot.org