Human RAB5A protein (Recombinant) (N-His) (STJP004280)

SKU:
STJP004280
£328.50 - £1,437.50
Free Shipping
Processing The item has been added

Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RAB5A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RAB5A
Gene ID: 5868
Uniprot ID: RAB5A_HUMAN
Immunogen Region: Asp136-Asn215
Immunogen: Homo sapiens (Human)
Function Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulation of filopodia extension. Required for the exosomal release of SDCBP, CD63, PDCD6IP and syndecan. Regulates maturation of apoptotic cell-containing phagosomes, probably downstream of DYN2 and PIK3C3.
Protein Name Ras-Related Protein Rab-5a
Database Links Reactome: R-HSA-1660499
Reactome: R-HSA-8854214
Reactome: R-HSA-8856828
Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Reactome: R-HSA-9636383
Reactome: R-HSA-9820960
Reactome: R-HSA-983231
Cellular Localisation Cell Membrane
Lipid-Anchor
Cytoplasmic Side
Early Endosome Membrane
Melanosome
Cytoplasmic Vesicle
Cell Projection
Ruffle
Membrane
Cytoplasm
Cytosol
Phagosome Membrane
Endosome Membrane
Enriched In Stage I Melanosomes
Alternates Between Membrane-Bound And Cytosolic Forms (Probable)
Alternative Protein Names Ras-Related Protein Rab-5a protein
RAB5A protein
RAB5 protein

Information sourced from Uniprot.org