| Function | Catalytic subunit of the Rab3 GTPase-activating (Rab3GAP) complex composed of RAB3GAP1 and RAB3GAP2, which has GTPase-activating protein (GAP) activity towards various Rab3 subfamily members (RAB3A, RAB3B, RAB3C and RAB3D), RAB5A and RAB43, and guanine nucleotide exchange factor (GEF) activity towards RAB18. As part of the Rab3GAP complex, acts as a GAP for Rab3 proteins by converting active RAB3-GTP to the inactive form RAB3-GDP. Rab3 proteins are involved in regulated exocytosis of neurotransmitters and hormones. The Rab3GAP complex, acts as a GEF for RAB18 by promoting the conversion of inactive RAB18-GDP to the active form RAB18-GTP. Recruits and stabilizes RAB18 at the cis-Golgi membrane in fibroblasts where RAB18 is most likely activated. Also involved in RAB18 recruitment at the endoplasmic reticulum (ER) membrane where it maintains proper ER structure. Required for normal eye and brain development. May participate in neurodevelopmental processes such as proliferation, migration and differentiation before synapse formation, and non-synaptic vesicular release of neurotransmitters. |
| Protein Name | Rab3 Gtpase-Activating Protein Catalytic SubunitRab3 Gtpase-Activating Protein 130 Kda SubunitRab3-Gap P130Rab3-Gap |
| Database Links | Reactome: R-HSA-6811436Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmEndoplasmic ReticulumGolgi ApparatusCis-Golgi NetworkIn NeuronsEnriched In The Synaptic Soluble FractionLocalized To The Cis-Golgi In Fibroblasts |
| Alternative Protein Names | Rab3 Gtpase-Activating Protein Catalytic Subunit proteinRab3 Gtpase-Activating Protein 130 Kda Subunit proteinRab3-Gap P130 proteinRab3-Gap proteinRAB3GAP1 proteinKIAA0066 proteinRAB3GAP protein |
Information sourced from Uniprot.org
