| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Required for the integrity and for normal function of the Golgi apparatus and the trans-Golgi network. Plays a role in insulin-stimulated translocation of GLUT4 to the cell membrane. Plays a role in M6PR transport from the trans-Golgi network to endosomes. Plays a role in the internalization of EGFR from the cell membrane into endosomes. Plays a role in the maturation of phagosomes that engulf pathogens, such as S.aureus and M.tuberculosis. |
| Protein Name | Ras-Related Protein Rab-31Ras-Related Protein Rab-22b |
| Database Links | Reactome: R-HSA-6798695Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | Golgi ApparatusTrans-Golgi NetworkTrans-Golgi Network MembraneLipid-AnchorCytoplasmic SideEarly EndosomeCytoplasmic VesiclePhagosomePhagosome MembraneRapidly Recruited To Phagosomes Containing SAureus Or MTuberculosis |
| Alternative Protein Names | Ras-Related Protein Rab-31 proteinRas-Related Protein Rab-22b proteinRAB31 proteinRAB22B protein |
Information sourced from Uniprot.org
