| Function | The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Plays a role in the initial events of the autophagic vacuole development which take place at specialized regions of the endoplasmic reticulum. Regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments. Required to modulate the compacted morphology of the Golgi. Promotes the recruitment of lipid phosphatase MTMR6 to the endoplasmic reticulum-Golgi intermediate compartment. |
| Protein Name | Ras-Related Protein Rab-1b |
| Database Links | Reactome: R-HSA-162658Reactome: R-HSA-204005Reactome: R-HSA-6807878Reactome: R-HSA-6811434Reactome: R-HSA-8873719Reactome: R-HSA-8876198 |
| Cellular Localisation | CytoplasmMembraneLipid-AnchorCytoplasmic SidePreautophagosomal Structure MembranePerinuclear RegionTargeted By Rep1 To Membranes Of Specific Subcellular Compartments Including Endoplasmic ReticulumGolgi ApparatusAnd Intermediate Vesicles Between These Two CompartmentsIn The Gdp-FormColocalizes With Gdi In The CytoplasmCo-Localizes With Mtmr6 To The Endoplasmic Reticulum-Golgi Intermediate Compartment And To The Peri-Golgi Region |
| Alternative Protein Names | Ras-Related Protein Rab-1b proteinRAB1B protein |
Information sourced from Uniprot.org
