Human RAB12 protein (Recombinant) (N-His) (STJP007689)

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STJP007689
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human RAB12-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: RAB12
Gene ID: 201475
Uniprot ID: RAB12_HUMAN
Immunogen Region: Asp40-Lys207
Immunogen: Homo sapiens (Human)
Function The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. That Rab may play a role in protein transport from recycling endosomes to lysosomes regulating, for instance, the degradation of the transferrin receptor. Involved in autophagy.
Protein Name Ras-Related Protein Rab-12
Database Links Reactome: R-HSA-8873719
Reactome: R-HSA-8876198
Cellular Localisation Recycling Endosome Membrane
Lipid-Anchor
Cytoplasmic Side
Lysosome Membrane
Golgi Apparatus Membrane
Cytoplasmic Vesicle
Autophagosome
Alternative Protein Names Ras-Related Protein Rab-12 protein
RAB12 protein

Information sourced from Uniprot.org

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