Human PTPRR protein (Recombinant) (N-His) (STJP011344)

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STJP011344
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PTPRR-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTPRR
Gene ID: 5801
Uniprot ID: PTPRR_HUMAN
Immunogen Region: Met1-Ser171
Immunogen: Homo sapiens (Human)
Function Sequesters mitogen-activated protein kinases (MAPKs) such as MAPK1, MAPK3 and MAPK14 in the cytoplasm in an inactive form. The MAPKs bind to a dephosphorylated kinase interacting motif, phosphorylation of which by the protein kinase A complex releases the MAPKs for activation and translocation into the nucleus.
Protein Name Receptor-Type Tyrosine-Protein Phosphatase R
R-Ptp-R
Ch-1ptpase
Nc-Ptpcom1
Protein-Tyrosine Phosphatase Pcptp1
Cellular Localisation Secreted
Isoform Alpha: Cell Membrane
Single-Pass Type I Membrane Protein
Isoform Delta: Cytoplasm
Perinuclear Region
Locates To The Perinuclear Areas Within The Cytoplasm
Isoform Gamma: Cytoplasm
Alternative Protein Names Receptor-Type Tyrosine-Protein Phosphatase R protein
R-Ptp-R protein
Ch-1ptpase protein
Nc-Ptpcom1 protein
Protein-Tyrosine Phosphatase Pcptp1 protein
PTPRR protein
ECPTP protein
PTPRQ protein

Information sourced from Uniprot.org

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