| Post Translational Modifications | N-glycosylated. O-glycosylated with core 1 or possibly core 8 glycans. Subject to proteolytic cleavage at multiple sites. Subject to cleavage on a pair of basic residues. On exocytosis of secretory granules in pancreatic beta-cells ICA512-TMF is transiently inserted in the plasma-membrane and cleaved by mu-type calpain CPN1 to yield ICA512-CCF. Sumoylated at two sites including Lys-754. Sumoylation decreases interaction with STAT5. |
| Function | Plays a role in vesicle-mediated secretory processes. Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets. Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation. Plays a role in insulin secretion in response to glucose stimuli. Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain. In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Required to maintain normal levels of renin expression and renin release. Seems to lack intrinsic enzyme activity. May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization. ICA512-transmembrane fragment: ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs).binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN.the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2. ICA512-cleaved cytosolic fragment: ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes.the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4. Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3. ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis. |
| Protein Name | Receptor-Type Tyrosine-Protein Phosphatase-Like NR-Ptp-NIslet Cell Antigen 512Ica 512Islet Cell Autoantigen 3Ptp Ia-2 Cleaved Into - Ica512-N-Terminal FragmentIca512-Ntf - Ica512-Transmembrane FragmentIca512-Tmf - Ica512-Cleaved Cytosolic FragmentIca512-Ccf |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCytoplasmic VesicleSecretory Vesicle MembranePerikaryonCell ProjectionAxonSynapseCell MembraneEndosomeDetected On Neuronal Secretory VesiclesBut Not On Synaptic VesiclesColocalizes With Insulin-Containing Secretory GranulesPrimarily Detected On Secretory Vesicle MembranesTransiently Found At The Cell MembraneWhen Secretory Vesicles Fuse With The Cell Membrane To Release Their CargoIs Then Endocytosed And Recycled To Secretory Vesicles Via The Golgi Apparatus MembranesIca512-Transmembrane Fragment: Cytoplasmic VesicleIca512-Cleaved Cytosolic Fragment: Nucleus |
| Alternative Protein Names | Receptor-Type Tyrosine-Protein Phosphatase-Like N proteinR-Ptp-N proteinIslet Cell Antigen 512 proteinIca 512 proteinIslet Cell Autoantigen 3 proteinPtp Ia-2 Cleaved Into - Ica512-N-Terminal Fragment proteinIca512-Ntf - Ica512-Transmembrane Fragment proteinIca512-Tmf - Ica512-Cleaved Cytosolic Fragment proteinIca512-Ccf proteinPTPRN proteinICA3 proteinICA512 protein |
Information sourced from Uniprot.org
