Human PTGIS protein (Recombinant) (N-His) (STJP005503)

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STJP005503
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PTGIS-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PTGIS
Gene ID: 5740
Uniprot ID: PTGIS_HUMAN
Immunogen Region: Thr24-Pro500
Immunogen: Homo sapiens (Human)
Function Catalyzes the biosynthesis and metabolism of eicosanoids. Catalyzes the isomerization of prostaglandin H2 to prostacyclin (= prostaglandin I2), a potent mediator of vasodilation and inhibitor of platelet aggregation. Additionally, displays dehydratase activity, toward hydroperoxyeicosatetraenoates (HPETEs), especially toward (15S)-hydroperoxy-(5Z,8Z,11Z,13E)-eicosatetraenoate (15(S)-HPETE).
Protein Name Prostacyclin Synthase
Hydroperoxy Icosatetraenoate Dehydratase
Prostaglandin I2 Synthase
Database Links Reactome: R-HSA-197264
Reactome: R-HSA-211979
Reactome: R-HSA-2162123
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative Protein Names Prostacyclin Synthase protein
Hydroperoxy Icosatetraenoate Dehydratase protein
Prostaglandin I2 Synthase protein
PTGIS protein
CYP8 protein
CYP8A1 protein

Information sourced from Uniprot.org

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