| Function | Transcription factor implicated in the cell fate determination in various organs. Binds to the E-box consensus sequence 5'-CANNTG-3'. Plays a role in early and late pancreas development and differentiation. Important for determining whether cells allocated to the pancreatic buds continue towards pancreatic organogenesis or revert back to duodenal fates. May be involved in the maintenance of exocrine pancreas-specific gene expression including ELA1 and amylase. Required for the formation of pancreatic acinar and ductal cells. Plays an important role in cerebellar development. Directly regulated by FOXN4 and RORC during retinal development, FOXN4-PTF1A pathway plays a central role in directing the differentiation of retinal progenitors towards horizontal and amacrine fates. |
| Protein Name | Pancreas Transcription Factor 1 Subunit AlphaClass A Basic Helix-Loop-Helix Protein 29Bhlha29Pancreas-Specific Transcription Factor 1aBhlh Transcription Factor P48P48 Dna-Binding Subunit Of Transcription Factor Ptf1Ptf1-P48 |
| Database Links | Reactome: R-HSA-210747 |
| Cellular Localisation | NucleusCytoplasmIn Chronic Pancreatitis Associated With Pancreas Cancer Preferentially Accumulates In The Cytoplasm Of Acinar/Ductular ComplexesIn The Cytoplasm Loses Its Ability To Form The Ptf1 Complex |
| Alternative Protein Names | Pancreas Transcription Factor 1 Subunit Alpha proteinClass A Basic Helix-Loop-Helix Protein 29 proteinBhlha29 proteinPancreas-Specific Transcription Factor 1a proteinBhlh Transcription Factor P48 proteinP48 Dna-Binding Subunit Of Transcription Factor Ptf1 proteinPtf1-P48 proteinPTF1A proteinBHLHA29 proteinPTF1P48 protein |
Information sourced from Uniprot.org
