| Function | Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3. |
| Protein Name | Prospero Homeobox Protein 1Homeobox Prospero-Like Protein Prox1Prox-1 |
| Cellular Localisation | NucleusRorg Promotes Its Nuclear Localization |
| Alternative Protein Names | Prospero Homeobox Protein 1 proteinHomeobox Prospero-Like Protein Prox1 proteinProx-1 proteinPROX1 protein |
Information sourced from Uniprot.org
