| Host: | E.coli |
| Applications: | SDS-PAGE |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human Profilin 2/PFN2-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications. |
| Formulation: | Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol 1mM DTT |
| Concentration: | 1 mg/mL |
| Storage Instruction: | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | PFN2 |
| Gene ID: | 5217 |
| Uniprot ID: | PROF2_HUMAN |
| Immunogen Region: | 1-140aa |
| Accession Number: | AAH18049 |
| Immunogen: | Human |
| Immunogen Sequence: |
| Tissue Specificity | Highly expressed in brain, skeletal muscle and kidney and less strongly in heart, placenta, lung and liver. |
| Function | Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. |
| Protein Name | Profilin-2Profilin Ii |
| Database Links | Reactome: R-HSA-376176Reactome: R-HSA-5663220 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Protein Names | Profilin-2 proteinProfilin Ii proteinPFN2 protein |
Information sourced from Uniprot.org