Human PRG4 protein (Recombinant) (N-His) (STJP005807)

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STJP005807
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PRG4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PRG4
Gene ID: 10216
Uniprot ID: PRG4_HUMAN
Immunogen Region: Val1151-Gly1241
Immunogen: Homo sapiens (Human)
Post Translational Modifications N-glycosylated. O-glycosylated.contains glycosaminoglycan chondroitin sulfate and keratan sulfate. O-glycosylated with sialylated oligosaccharides which are predominantly represented by the monosialylated core type I structure, NeuNAcalpha2-3Galbeta1-3GalNAc, with smaller amounts of disialylated O-glycans. The disulfide bond between Cys-1146 and Cys-1403 is essential for protein cleavage. Proteolytically cleaved by cathepsin CTSG.
Function Plays a role in boundary lubrication within articulating joints. Prevents protein deposition onto cartilage from synovial fluid by controlling adhesion-dependent synovial growth and inhibiting the adhesion of synovial cells to the cartilage surface. Isoform F plays a role as a growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages.
Protein Name Proteoglycan 4
Lubricin
Megakaryocyte-Stimulating Factor
Superficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part
Cellular Localisation Secreted
Alternative Protein Names Proteoglycan 4 protein
Lubricin protein
Megakaryocyte-Stimulating Factor protein
Superficial Zone Proteoglycan Cleaved Into - Proteoglycan 4 C-Terminal Part protein
PRG4 protein
MSF protein
SZP protein

Information sourced from Uniprot.org