Human PPP5C protein (Recombinant) (N-His) (STJP008162)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PPP5C-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PPP5C |
| Gene ID | 5536 |
| Uniprot ID | PPP5_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Asp22-Met499 |
Additional Info
| Post Translational Modifications | Activated by at least two different proteolytic cleavages producing a 56 kDa and a 50 kDa form. |
| Function | Serine/threonine-protein phosphatase that dephosphorylates a myriad of proteins involved in different signaling pathways including the kinases CSNK1E, ASK1/MAP3K5, PRKDC and RAF1, the nuclear receptors NR3C1, PPARG, ESR1 and ESR2, SMAD proteins and TAU/MAPT. Implicated in wide ranging cellular processes, including apoptosis, differentiation, DNA damage response, cell survival, regulation of ion channels or circadian rhythms, in response to steroid and thyroid hormones, calcium, fatty acids, TGF-beta as well as oxidative and genotoxic stresses. Participates in the control of DNA damage response mechanisms such as checkpoint activation and DNA damage repair through, for instance, the regulation ATM/ATR-signaling and dephosphorylation of PRKDC and TP53BP1. Inhibits ASK1/MAP3K5-mediated apoptosis induced by oxidative stress. Plays a positive role in adipogenesis, mainly through the dephosphorylation and activation of PPARG transactivation function. Also dephosphorylates and inhibits the anti-adipogenic effect of NR3C1. Regulates the circadian rhythms, through the dephosphorylation and activation of CSNK1E. May modulate TGF-beta signaling pathway by the regulation of SMAD3 phosphorylation and protein expression levels. Dephosphorylates and may play a role in the regulation of TAU/MAPT. Through their dephosphorylation, may play a role in the regulation of ions channels such as KCNH2. Dephosphorylate FNIP1, disrupting interaction with HSP90AA1/Hsp90. |
| Protein Name | Serine/Threonine-Protein Phosphatase 5Pp5Protein Phosphatase TPp-TPpt |
| Database Links | Reactome: R-HSA-5675221Reactome: R-HSA-5693565Reactome: R-HSA-8939211 |
| Cellular Localisation | NucleusCytoplasmCell MembranePredominantly NuclearBut Also Present In The CytoplasmTranslocates From The Cytoplasm To The Plasma Membrane In A Rac1-Dependent Manner |
| Alternative Protein Names | Serine/Threonine-Protein Phosphatase 5 proteinPp5 proteinProtein Phosphatase T proteinPp-T proteinPpt proteinPPP5C proteinPPP5 protein |
Information sourced from Uniprot.org