| Post Translational Modifications | Phosphorylated by CIT (Rho-associated kinase). Phosphorylated cooperatively by ROCK1 and CDC42BP on Thr-696. Phosphorylated on upon DNA damage, probably by ATM or ATR. In vitro, phosphorylation of Ser-695 by PKA and PKG appears to prevent phosphorylation of the inhibitory site Thr-696, probably mediated by PRKG1. Phosphorylation at Ser-445, Ser-472 and Ser-910 by NUAK1 promotes interaction with 14-3-3, leading to inhibit interaction with myosin light chain MLC2, preventing dephosphorylation of MLC2. May be phosphorylated at Thr-696 by DMPK.may inhibit the myosin phosphatase activity. Phosphorylated at Ser-473 by CDK1 during mitosis, creating docking sites for the POLO box domains of PLK1. Subsequently, PLK1 binds and phosphorylates PPP1R12A. |
| Function | Key regulator of protein phosphatase 1C (PPP1C). Mediates binding to myosin. As part of the PPP1C complex, involved in dephosphorylation of PLK1. Capable of inhibiting HIF1AN-dependent suppression of HIF1A activity. |
| Protein Name | Protein Phosphatase 1 Regulatory Subunit 12aMyosin Phosphatase-Targeting Subunit 1Myosin Phosphatase Target Subunit 1Protein Phosphatase Myosin-Binding Subunit |
| Database Links | Reactome: R-HSA-2565942Reactome: R-HSA-5625740Reactome: R-HSA-5625900Reactome: R-HSA-5627117Reactome: R-HSA-5627123 |
| Cellular Localisation | CytoplasmCytoskeletonStress FiberAlso Along Actomyosin Filaments |
| Alternative Protein Names | Protein Phosphatase 1 Regulatory Subunit 12a proteinMyosin Phosphatase-Targeting Subunit 1 proteinMyosin Phosphatase Target Subunit 1 proteinProtein Phosphatase Myosin-Binding Subunit proteinPPP1R12A proteinMBS proteinMYPT1 protein |
Information sourced from Uniprot.org
