| Function | Protein phosphatase that associates with over 200 regulatory proteins to form highly specific holoenzymes which dephosphorylate hundreds of biological targets. Protein phosphatase 1 (PP1) is essential for cell division, and participates in the regulation of glycogen metabolism, muscle contractility and protein synthesis. Dephosphorylates RPS6KB1. Involved in regulation of ionic conductances and long-term synaptic plasticity. May play an important role in dephosphorylating substrates such as the postsynaptic density-associated Ca(2+)/calmodulin dependent protein kinase II. Component of the PTW/PP1 phosphatase complex, which plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. In balance with CSNK1D and CSNK1E, determines the circadian period length, through the regulation of the speed and rhythmicity of PER1 and PER2 phosphorylation. May dephosphorylate CSNK1D and CSNK1E. Regulates the recruitment of the SKA complex to kinetochores. Dephosphorylates the 'Ser-418' residue of FOXP3 in regulatory T-cells (Treg) from patients with rheumatoid arthritis, thereby inactivating FOXP3 and rendering Treg cells functionally defective. Together with PPP1CA (PP1-alpha subunit), dephosphorylates IFIH1/MDA5 and RIG-I leading to their activation and a functional innate immune response. Core component of the SHOC2-MRAS-PP1c (SMP) holophosphatase complex that regulates the MAPK pathway activation. The SMP complex specifically dephosphorylates the inhibitory phosphorylation at 'Ser-259' of RAF1 kinase, 'Ser-365' of BRAF kinase and 'Ser-214' of ARAF kinase, stimulating their kinase activities. The SMP complex enhances the dephosphorylation activity and substrate specificity of PP1c. |
| Protein Name | Serine/Threonine-Protein Phosphatase Pp1-Gamma Catalytic SubunitPp-1gProtein Phosphatase 1c Catalytic Subunit |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-163560Reactome: R-HSA-2173788Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-400253Reactome: R-HSA-5663220Reactome: R-HSA-5673000Reactome: R-HSA-68877Reactome: R-HSA-9648025Reactome: R-HSA-9726840Reactome: R-HSA-9726842Reactome: R-HSA-9828806 |
| Cellular Localisation | CytoplasmNucleusNucleolusNucleoplasmNucleus SpeckleChromosomeCentromereKinetochoreCleavage FurrowMidbodyMitochondrionCytoskeletonMicrotubule Organizing CenterColocalizes With Spz1 In The NucleusColocalizes With Uri1 At MitochondrionRapidly Exchanges Between The NucleolarNucleoplasmic And Cytoplasmic CompartmentsHighly Mobile In Cells And Can Be Relocalized Through Interaction With Targeting SubunitsIn The Presence Of Ppp1r8 Relocalizes From The Nucleolus To Nuclear SpecklesShows A Dynamic Targeting To Specific Sites Throughout The Cell CycleHighly Concentrated In Nucleoli Of Interphase Cells And Localizes At Kinetochores Early In MitosisRelocalization To Chromosome-Containing Regions Occurs At The Transition From Early To Late AnaphaseAlso Accumulates At The Cleavage Furrow And Midbody By TelophaseColocalizes With Dynlt4 In The Microtubule Organizing Center (Mtoc) |
| Alternative Protein Names | Serine/Threonine-Protein Phosphatase Pp1-Gamma Catalytic Subunit proteinPp-1g proteinProtein Phosphatase 1c Catalytic Subunit proteinPPP1CC protein |
Information sourced from Uniprot.org
