Human PPM1D protein (Recombinant) (N-His) (STJP010651)

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STJP010651
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PPM1D-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PPM1D
Gene ID: 8493
Uniprot ID: PPM1D_HUMAN
Immunogen Region: Ser96-Leu395
Immunogen: Homo sapiens (Human)
Function Involved in the negative regulation of p53 expression. Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Mediates MAPK14 dephosphorylation and inactivation. Is also an important regulator of global heterochromatin silencing and critical in maintaining genome integrity.
Protein Name Protein Phosphatase 1d
Protein Phosphatase 2c Isoform Delta
Pp2c-Delta
Protein Phosphatase Magnesium-Dependent 1 Delta
P53-Induced Protein Phosphatase 1
Database Links Reactome: R-HSA-8878166
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Alternative Protein Names Protein Phosphatase 1d protein
Protein Phosphatase 2c Isoform Delta protein
Pp2c-Delta protein
Protein Phosphatase Magnesium-Dependent 1 Delta protein
P53-Induced Protein Phosphatase 1 protein
PPM1D protein
WIP1 protein

Information sourced from Uniprot.org

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