Human PPM1A protein (Recombinant) (N-His) (STJP004631)

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STJP004631
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PPM1A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PPM1A
Gene ID: 5494
Uniprot ID: PPM1A_HUMAN
Immunogen Region: Gly2-Trp382
Immunogen: Homo sapiens (Human)
Function Enzyme with a broad specificity. Negatively regulates TGF-beta signaling through dephosphorylating SMAD2 and SMAD3, resulting in their dissociation from SMAD4, nuclear export of the SMADs and termination of the TGF-beta-mediated signaling. Dephosphorylates PRKAA1 and PRKAA2. Plays an important role in the termination of TNF-alpha-mediated NF-kappa-B activation through dephosphorylating and inactivating IKBKB/IKKB.
Protein Name Protein Phosphatase 1a
Protein Phosphatase 2c Isoform Alpha
Pp2c-Alpha
Protein Phosphatase Ia
Database Links Reactome: R-HSA-2173795
Reactome: R-HSA-380972
Cellular Localisation Nucleus
Cytoplasm
Cytosol
Membrane
Lipid-Anchor
Weakly Associates At The Membrane And N-Myristoylation Mediates The Membrane Localization
Alternative Protein Names Protein Phosphatase 1a protein
Protein Phosphatase 2c Isoform Alpha protein
Pp2c-Alpha protein
Protein Phosphatase Ia protein
PPM1A protein
PPPM1A protein

Information sourced from Uniprot.org

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