Human PPARGC1B protein (Recombinant) (N-His) (STJP010998)
SPECIFICATIONS
HostE.coli
ImmunogenHomo sapiens (Human)
General Information
| Short Description | Recombinant-Human PPARGC1B-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | PPARGC1B |
| Gene ID | 133522 |
| Uniprot ID | PRGC2_HUMAN |
| Immunogen | Homo sapiens (Human) |
| Immunogen Region | Ser886-His1023 |
Additional Info
| Function | Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. |
| Protein Name | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-BetaPgc-1-BetaPpar-Gamma Coactivator 1-BetaPpargc-1-BetaPgc-1-Related Estrogen Receptor Alpha Coactivator |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-8939902Reactome: R-HSA-9841922Reactome: R-HSA-9844594 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta proteinPgc-1-Beta proteinPpar-Gamma Coactivator 1-Beta proteinPpargc-1-Beta proteinPgc-1-Related Estrogen Receptor Alpha Coactivator proteinPPARGC1B proteinPERC proteinPGC1 proteinPGC1B proteinPPARGC1 protein |
Information sourced from Uniprot.org