Human PPARGC1B protein (Recombinant) (N-His) (STJP010998)

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STJP010998
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PPARGC1B-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PPARGC1B
Gene ID: 133522
Uniprot ID: PRGC2_HUMAN
Immunogen Region: Ser886-His1023
Immunogen: Homo sapiens (Human)
Function Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.
Protein Name Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta
Pgc-1-Beta
Ppar-Gamma Coactivator 1-Beta
Ppargc-1-Beta
Pgc-1-Related Estrogen Receptor Alpha Coactivator
Database Links Reactome: R-HSA-1989781
Reactome: R-HSA-2151201
Reactome: R-HSA-8939902
Reactome: R-HSA-9844594
Cellular Localisation Nucleus
Alternative Protein Names Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Beta protein
Pgc-1-Beta protein
Ppar-Gamma Coactivator 1-Beta protein
Ppargc-1-Beta protein
Pgc-1-Related Estrogen Receptor Alpha Coactivator protein
PPARGC1B protein
PERC protein
PGC1 protein
PGC1B protein
PPARGC1 protein

Information sourced from Uniprot.org

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