| Post Translational Modifications | Phosphorylation by AMPK in skeletal muscle increases activation of its own promoter. Phosphorylated by CLK2. Heavily acetylated by KAT2A/GCN5 under conditions of high nutrients, leading to inactivation of PPARGC1A. Deacetylated by SIRT1 in low nutrients/high NAD conditions, leading to its activation. Ubiquitinated. Ubiquitination by RNF34 induces proteasomal degradation. |
| Function | Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Acts as a key regulator of gluconeogenesis: stimulates hepatic gluconeogenesis by increasing the expression of gluconeogenic enzymes, and acting together with FOXO1 to promote the fasting gluconeogenic program. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner. Also involved in the integration of the circadian rhythms and energy metabolism. Required for oscillatory expression of clock genes, such as BMAL1 and NR1D1, through the coactivation of RORA and RORC, and metabolic genes, such as PDK4 and PEPCK. |
| Protein Name | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-AlphaPgc-1-AlphaPpar-Gamma Coactivator 1-AlphaPpargc-1-AlphaLigand Effect Modulator 6 |
| Database Links | Reactome: R-HSA-1989781Reactome: R-HSA-2151201Reactome: R-HSA-2151209Reactome: R-HSA-381340Reactome: R-HSA-3899300Reactome: R-HSA-400253Reactome: R-HSA-8939902Reactome: R-HSA-9615017Reactome: R-HSA-9707616Reactome: R-HSA-9844594Reactome: R-HSA-9854907 |
| Cellular Localisation | Isoform 1: NucleusNucleusPml BodyIsoform B4: NucleusIsoform B4-8a: CytoplasmIsoform B5: NucleusIsoform 9: Nucleus |
| Alternative Protein Names | Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha proteinPgc-1-Alpha proteinPpar-Gamma Coactivator 1-Alpha proteinPpargc-1-Alpha proteinLigand Effect Modulator 6 proteinPPARGC1A proteinLEM6 proteinPGC1 proteinPGC1A proteinPPARGC1 protein |
Information sourced from Uniprot.org
