| Function | Transcription factor that plays a key role in neuronal differentiation. Binds preferentially to the recognition sequence which consists of two distinct half-sites, ('GCAT') and ('TAAT'), separated by a non-conserved spacer region of 0, 2, or 3 nucleotides. Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. The combination of three transcription factors, ASCL1, POU3F2/BRN2 and MYT1L, is sufficient to reprogram fibroblasts and other somatic cells into induced neuronal (iN) cells in vitro. Acts downstream of ASCL1, accessing chromatin that has been opened by ASCL1, and promotes transcription of neuronal genes. |
| Protein Name | Pou Domain - Class 3 - Transcription Factor 2Brain-Specific Homeobox/Pou Domain Protein 2Brain-2Brn-2Nervous System-Specific Octamer-Binding Transcription Factor N-Oct-3Octamer-Binding Protein 7Oct-7Octamer-Binding Transcription Factor 7Otf-7 |
| Database Links | Reactome: R-HSA-9619665Reactome: R-HSA-9824594Reactome: R-HSA-9856649 |
| Cellular Localisation | Nucleus |
| Alternative Protein Names | Pou Domain - Class 3 - Transcription Factor 2 proteinBrain-Specific Homeobox/Pou Domain Protein 2 proteinBrain-2 proteinBrn-2 proteinNervous System-Specific Octamer-Binding Transcription Factor N-Oct-3 proteinOctamer-Binding Protein 7 proteinOct-7 proteinOctamer-Binding Transcription Factor 7 proteinOtf-7 proteinPOU3F2 proteinBRN2 proteinOCT7 proteinOTF7 protein |
Information sourced from Uniprot.org
