| Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III (Pol III) which synthesizes small non-coding RNAs including 5S rRNA, snRNAs, tRNAs and miRNAs from at least 500 distinct genomic loci. Acts as a long tether that bridges POLR3C/RPC3-POLR3F/RPC6-POLR3G/RPC7 heterotrimer and the mobile stalk of Pol III, coordinating the dynamics of Pol III stalk and clamp modules during the transition from apo to elongation state. Pol III exists as two alternative complexes defined by the mutually exclusive incorporation of subunit POLR3G/RPC7alpha or POLR3GL/RPC7beta. POLR3G/RPC7alpha modulates Pol III transcriptome by specifically enhancing the transcription of snaR-A non-coding RNAs. At resting state, occupies the active site of apo Pol III and keeps Pol III in an autoinhibitory mode, preventing non-specific transcription. Pol III plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as a nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs), induce type I interferon and NF-kappa-B through the RIG-I pathway. |
| Protein Name | Dna-Directed Rna Polymerase Iii Subunit Rpc7Rna Polymerase Iii Subunit C7Dna-Directed Rna Polymerase Iii Subunit GRna Polymerase Iii 32 Kda Apha SubunitRpc32-AlphaRna Polymerase Iii 32 Kda SubunitRpc32 |
| Database Links | Reactome: R-HSA-1834949Reactome: R-HSA-73780Reactome: R-HSA-73980Reactome: R-HSA-749476Reactome: R-HSA-76061Reactome: R-HSA-76066Reactome: R-HSA-76071 |
| Cellular Localisation | NucleusCytoplasmExcluded From NucleoliIn Zygotes And The 2-Cell Stage EmbryosMainly In The CytoplasmStarts To Localize To The Nucleus In The 8-16 Cell Stage Embryo And Early Blastocysts |
| Alternative Protein Names | Dna-Directed Rna Polymerase Iii Subunit Rpc7 proteinRna Polymerase Iii Subunit C7 proteinDna-Directed Rna Polymerase Iii Subunit G proteinRna Polymerase Iii 32 Kda Apha Subunit proteinRpc32-Alpha proteinRna Polymerase Iii 32 Kda Subunit proteinRpc32 proteinPOLR3G protein |
Information sourced from Uniprot.org
