| Post Translational Modifications | Monoubiquitinated. Protein monoubiquitination prevents POLI binding to ubiquitin via the ubiquitin-binding motif 1 and ubiquitin-binding motif 2. |
| Function | Error-prone DNA polymerase specifically involved in DNA repair. Plays an important role in translesion synthesis, where the normal high-fidelity DNA polymerases cannot proceed and DNA synthesis stalls. Favors Hoogsteen base-pairing in the active site. Inserts the correct base with high-fidelity opposite an adenosine template. Exhibits low fidelity and efficiency opposite a thymidine template, where it will preferentially insert guanosine. May play a role in hypermutation of immunoglobulin genes. Forms a Schiff base with 5'-deoxyribose phosphate at abasic sites, but may not have lyase activity. |
| Protein Name | Dna Polymerase IotaEta2Rad30 Homolog B |
| Database Links | Reactome: R-HSA-5656121Reactome: R-HSA-5656169 |
| Cellular Localisation | NucleusBinding To Ubiquitin Mediates Localization To Replication Forks After Uv-Induced Dna Damage |
| Alternative Protein Names | Dna Polymerase Iota proteinEta2 proteinRad30 Homolog B proteinPOLI proteinRAD30B protein |
Information sourced from Uniprot.org
