Human PNOC protein (Recombinant) (N-His) (STJP005339)

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STJP005339
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PNOC-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PNOC
Gene ID: 5368
Uniprot ID: PNOC_HUMAN
Immunogen Region: Ser20-Val176
Immunogen: Homo sapiens (Human)
Post Translational Modifications Specific enzymatic cleavages at paired basic residues probably yield other active peptides besides nociceptin. The N-terminal domain contains 6 conserved cysteines thought to be involved in disulfide bonding and/or processing.
Function Nociceptin: Ligand of the opioid receptor-like receptor OPRL1. It may act as a transmitter in the brain by modulating nociceptive and locomotor behavior. May be involved in neuronal differentiation and development. Nocistatin: Blocks nociceptin action in pain transmission by inhibiting nociceptin-induced hyperalgesia and allodynia. Orphanin FQ2: Has potent analgesic activity.
Protein Name Prepronociceptin Cleaved Into - Nocistatin - Nociceptin
Orphanin Fq
Ppnoc - Orphanin Fq2
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-418594
Cellular Localisation Secreted
Alternative Protein Names Prepronociceptin Cleaved Into - Nocistatin - Nociceptin protein
Orphanin Fq protein
Ppnoc - Orphanin Fq2 protein
PNOC protein
OFQ protein

Information sourced from Uniprot.org

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