| Applications: | ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.59ng/mL |
| Detection Limit: | 1.56-100ng/mL |
| Short Description : | This PLXNB1 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in human tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | PLXNB1 |
| Gene ID: | 5364 |
| Uniprot ID: | PLXB1_HUMAN |
| Sample Type: | tissue homogenates or other biological fluids. |
| Tissue Specificity | Highly expressed in fetal kidney, and at slightly lower levels in fetal brain, lung and liver. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by ERBB2 and MET upon SEMA4D binding. Proteolytic processing favors heterodimerization with PLXNB2 and SEMA4D binding. |
| Function | Receptor for SEMA4D. Plays a role in GABAergic synapse development. Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development. Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton. Plays a role in axon guidance, invasive growth and cell migration. |
| Protein Name | Plexin-B1 Semaphorin Receptor Sep |
| Database Links | Reactome: R-HSA-416482 Reactome: R-HSA-416550 Reactome: R-HSA-416572 Reactome: R-HSA-9013405 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Secreted Isoform 3: Secreted |
| Alternative ELISA Names | Plexin-B1 ELISA kit Semaphorin Receptor Sep ELISA kit PLXNB1 ELISA kit KIAA0407 ELISA kit PLXN5 ELISA kit SEP ELISA kit |
| output |
Information sourced from Uniprot.org