| Tissue Specificity | Highly expressed in lung, upper airways and nasopharyngeal regions, including trachea and nasal epithelium (at protein level). Specifically expressed in the secretory ducts and submucosal glands of tracheobronchial tissues (at protein level). Also expressed in the eye where it is detected in lacrimal gland, eyelid, conjunctiva and cornea (at protein level). Specifically localizes to epithelial cell layers in cornea, eyelid (basal epithelium) and conjunctiva (at protein level). Detected within acinar cells and ducts in the lacrimal and Meibomian glands (at protein level). In lung, shows highest expression in the trachea and progressive decrease from proximal (bronchial) to distal (bronchiolar) airways. Also expressed in lung cancers and some other types of cancer. |
| Post Translational Modifications | May be N-glycosylated. |
| Function | Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC). Plays a role in the innate immune responses of the upper airways. Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae. Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus. Plays a role in the airway inflammatory response after exposure to irritants. May attract macrophages and neutrophils. |
| Protein Name | Bpi Fold-Containing Family A Member 1Lung-Specific Protein XNasopharyngeal Carcinoma-Related ProteinPalate Lung And Nasal Epithelium Clone ProteinSecretory Protein In Upper Respiratory TractsShort Plunc1Splunc1Tracheal Epithelium-Enriched ProteinVon Ebner Protein Hl |
| Database Links | Reactome: R-HSA-6803157 |
| Cellular Localisation | SecretedApical Side Of Airway Epithelial CellsDetected In Airway Surface LiquidNasal Mucus And Sputum |
| Alternative ELISA Names | Bpi Fold-Containing Family A Member 1 ELISA kitLung-Specific Protein X ELISA kitNasopharyngeal Carcinoma-Related Protein ELISA kitPalate Lung And Nasal Epithelium Clone Protein ELISA kitSecretory Protein In Upper Respiratory Tracts ELISA kitShort Plunc1 ELISA kitSplunc1 ELISA kitTracheal Epithelium-Enriched Protein ELISA kitVon Ebner Protein Hl ELISA kitBPIFA1 ELISA kitLUNX ELISA kitNASG ELISA kitPLUNC ELISA kitSPLUNC1 ELISA kitSPURT ELISA kitUNQ787 ELISA kitPRO1606 ELISA kit |
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Information sourced from Uniprot.org
