| Function | Catalyzes metal ion-induced ATP-independent rapid bidirectional and non-specific movement of phospholipids (lipid scrambling or lipid flip-flop) between the inner and outer leaflet of the plasma membrane and participates in the redistribution of phospholipids between membrane leaflets. Metal ions bind to the calcium-binding site and induce conformation change in the protein. Has a greater affi nity for Ca(2+) than Mg(2+) and Zn(2+). |
| Protein Name | Phospholipid Scramblase 4Pl Scramblase 4Ca(2+-Dependent Phospholipid Scramblase 4Cell Growth-Inhibiting Gene 43 ProteinTra1 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinLipid-AnchorCytoplasmic SideNucleusPalmitoylation Regulates Its Localization To The Cell Membrane Or The NucleusTrafficking To The Cell Membrane Is Dependent Upon Palmitoylation Whereas In The Absence Of PalmitoylationLocalizes To The Nucleus |
| Alternative Protein Names | Phospholipid Scramblase 4 proteinPl Scramblase 4 proteinCa(2+-Dependent Phospholipid Scramblase 4 proteinCell Growth-Inhibiting Gene 43 Protein proteinTra1 proteinPLSCR4 proteinGIG43 protein |
Information sourced from Uniprot.org