| Host: |
CHO cells |
| Note: |
STRICTLY FOR FURTHER RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human Platelet Derived Growth Factor-AA-protein was developed from cho cells. For use in research applications. |
| Conjugation: |
Unconjugated |
| Formulation: |
Lyophilised from 0.2 Mu m filtered mM NaCl, mM Tris solution pH7.0. |
| Dilution Range: |
Spin the vial and reconstite in distilled water to a concentration not less than 0.1 mg/mL. This can then be diluted into other buffers. |
| Storage Instruction: |
Can be stored in working aliquots at°C-°C C for one month, or at-20°C C for six months, with a carrier protein without detectable loss of activity. Avoid repeated freeze/thaw cycles. NA |
| Endotoxin: |
Endotoxin content was assayed using a LAL gel clot method. Endotoxin level was found to be less than.1 ng/µg (1EU/µg). NA |
| Immunoreactivity: |
The ED (50) was determinedby the dose-dependent stimulation of thymidine uptake by Balb/cT3 cells is ≤ ng/ml, corresponding to a specific activity of > x units/mg NA |
| Gene Symbol: |
PDGFA |
| Gene ID: |
5154 |
| Uniprot ID: |
PDGFA_HUMAN |
| Immunogen Region: |
Mature chain |
| Immunogen: |
Optimized DNA sequence encoding Human PDGF-AA mature chain was expressed in CHO Cells. NA |
| Immunogen Sequence: |
MRTLACLLLL GCGYLAHVLA EEAEIPREVI ERLARSQIHS IRDLQRLLEI DSVGSEDSLD TSLRAHGVHA TKHVPEKRPL PIRRKRSIEE AVPAVCKTRT VIYEIPRSQV DPTSANFLIW PPCVEVKRCT GCCNTSSVKC QPSRVHHRSV KVAKVEYVRK KPKLKEVQVR LEEHLECACA TTSLNPDYRE EDTGRPRESG KKRKRKRLKP T NA |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal lung alveolar septum formation during embryogenesis, normal development of the gastrointestinal tract, normal development of Leydig cells and spermatogenesis. Required for normal oligodendrocyte development and normal myelination in the spinal cord and cerebellum. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFB. |
| Protein Name | Platelet-Derived Growth Factor Subunit APdgf Subunit APdgf-1Platelet-Derived Growth Factor A ChainPlatelet-Derived Growth Factor Alpha Polypeptide |
| Database Links | Reactome: R-HSA-114608 P04085-1Reactome: R-HSA-1257604Reactome: R-HSA-186763Reactome: R-HSA-186797Reactome: R-HSA-2219530Reactome: R-HSA-3000171Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | SecretedReleased By Platelets Upon Wounding |
| Alternative Protein Names | Platelet-Derived Growth Factor Subunit A proteinPdgf Subunit A proteinPdgf-1 proteinPlatelet-Derived Growth Factor A Chain proteinPlatelet-Derived Growth Factor Alpha Polypeptide proteinPDGFA proteinPDGF1 protein |
Information sourced from Uniprot.org
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