| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of 20mM NaAc, 150mM NaCl, pH5.0. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | KLKB1 |
| Gene ID: | 3818 |
| Uniprot ID: | KLKB1_HUMAN |
| Immunogen Region: | Gly20-Ala638 |
| Immunogen: | Recombinant Human Plasma Kallikrein/KLKB1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Gly20-Ala638) of human Plasma Kallikrein/KLKB1 (Accession #NP_000883.2) fused with 6×His tag at the C-term |
| Immunogen Sequence: | GCLTQLYENAFFRGGDVASM YTPNAQYCQMRCTFHPRCLL FSFLPASSINDMEKRFGCFL KDSVTGTLPKVHRTGAVSGH SLKQCGHQISACHRDIYKGV DMRGVNFNVSKVSSVEECQK RCTNNIRCQFFSYATQTFHK AEYRNNCLLKYSPGGTPTAI KVLSNVESGFSLKPCALSEI GCHMNIFQHLAFSDVDVARV LTPDAFVCRTICTYHPNCLF FTFYTNVWKIESQRNVCLL |
| Tissue Specificity | Found in plasma (at protein level). |
| Function | Participates in the surface-dependent activation of blood coagulation. Activates, in a reciprocal reaction, coagulation factor XII/F12 after binding to negatively charged surfaces. Releases bradykinin from HMW kininogen and may also play a role in the renin-angiotensin system by converting prorenin into renin. |
| Protein Name | Plasma KallikreinFletcher FactorKininogeninPlasma PrekallikreinPkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain |
| Database Links | Reactome: R-HSA-140837Reactome: R-HSA-1592389Reactome: R-HSA-9657688Reactome: R-HSA-9657689 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Plasma Kallikrein proteinFletcher Factor proteinKininogenin proteinPlasma Prekallikrein proteinPkk Cleaved Into - Plasma Kallikrein Heavy Chain - Plasma Kallikrein Light Chain proteinKLKB1 proteinKLK3 protein |
Information sourced from Uniprot.org
