| Post Translational Modifications | The secretory phospholipase A2 receptor form may be produced by the action of metalloproteinases. It contains all extracellular domains and only lacks transmembrane and cytosolic regions. It is however unclear whether this form is produced by proteolytic cleavage as suggested by some experiments, or by alternative splicing, as in the case of isoform 2 that shares all characteristics of secretory phospholipase A2 receptor form. |
| Function | Receptor for secretory phospholipase A2 (sPLA2). Acts as a receptor for phospholipase sPLA2-IB/PLA2G1B but not sPLA2-IIA/PLA2G2A. Also able to bind to snake PA2-like toxins. Although its precise function remains unclear, binding of sPLA2 to its receptor participates in both positive and negative regulation of sPLA2 functions as well as clearance of sPLA2. Binding of sPLA2-IB/PLA2G1B induces various effects depending on the cell type, such as activation of the mitogen-activated protein kinase (MAPK) cascade to induce cell proliferation, the production of lipid mediators, selective release of arachidonic acid in bone marrow-derived mast cells. In neutrophils, binding of sPLA2-IB/PLA2G1B can activate p38 MAPK to stimulate elastase release and cell adhesion. May be involved in responses in pro-inflammatory cytokine productions during endotoxic shock. Also has endocytic properties and rapidly internalizes sPLA2 ligands, which is particularly important for the clearance of extracellular sPLA2s to protect their potent enzymatic activities. The soluble secretory phospholipase A2 receptor form is circulating and acts as a negative regulator of sPLA2 functions by blocking the biological functions of sPLA2-IB/PLA2G1B. In podocytes, binding of sPLA2-IB/PLA2G1B can regulate podocyte survival and glomerular homeostasis. |
| Protein Name | Secretory Phospholipase A2 ReceptorPla2-RPla2r180 Kda Secretory Phospholipase A2 ReceptorC-Type Lectin Domain Family 13 Member CM-Type Receptor Cleaved Into - Soluble Secretory Phospholipase A2 ReceptorSoluble Pla2-RSoluble Pla2r |
| Database Links | Reactome: R-HSA-1482788Reactome: R-HSA-1482801Reactome: R-HSA-1482839Reactome: R-HSA-1482922Reactome: R-HSA-1482925Reactome: R-HSA-1483166 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinSoluble Secretory Phospholipase A2 Receptor: SecretedIsoform 2: Secreted |
| Alternative Protein Names | Secretory Phospholipase A2 Receptor proteinPla2-R proteinPla2r protein180 Kda Secretory Phospholipase A2 Receptor proteinC-Type Lectin Domain Family 13 Member C proteinM-Type Receptor Cleaved Into - Soluble Secretory Phospholipase A2 Receptor proteinSoluble Pla2-R proteinSoluble Pla2r proteinPLA2R1 proteinCLEC13C protein |
Information sourced from Uniprot.org
