Human PLA1A protein (Recombinant) (N-His) (STJP005542)

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STJP005542
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PLA1A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PLA1A
Gene ID: 51365
Uniprot ID: PLA1A_HUMAN
Immunogen Region: Leu309-Lys452
Immunogen: Homo sapiens (Human)
Function Hydrolyzes the ester bond of the acyl group attached at the sn-1 position of phosphatidylserines (phospholipase A1 activity) and 1-acyl-2-lysophosphatidylserines (lysophospholipase activity) in the pathway of phosphatidylserines acyl chain remodeling. Cleaves phosphatidylserines exposed on the outer leaflet of the plasma membrane of apoptotic cells producing 2-acyl-1-lysophosphatidylserines, which in turn enhance mast cell activation and histamine production. Has no activity toward other glycerophospholipids including phosphatidylcholines, phosphatidylethanolamines, phosphatidic acids or phosphatidylinositols, or glycerolipids such as triolein. Isoform 2: Hydrolyzes lyso-PS but not PS.
Protein Name Phospholipase A1 Member A
Phosphatidylserine-Specific Phospholipase A1
Ps-Pla1
Database Links Reactome: R-HSA-1482801
Cellular Localisation Secreted
Alternative Protein Names Phospholipase A1 Member A protein
Phosphatidylserine-Specific Phospholipase A1 protein
Ps-Pla1 protein
PLA1A protein
NMD protein
PSPLA1 protein

Information sourced from Uniprot.org

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