| Post Translational Modifications | Phosphorylated by AKT2.required for interaction with YWHAG and subsequent localization away from desmosomes to the cytoplasm. Phosphorylation of Ser-118 by AKT2 promotes PKP1-driven cap-dependent mRNA translation and decreases intercellular adhesion, phosphorylation is promoted by insulin. Phosphorylation by RIPK4 at the N-terminus is required for its role in differentiation of keratinocytes and DSG1 localization at cell junctions. |
| Function | A component of desmosome cell-cell junctions which are required for positive regulation of cellular adhesion. Plays a role in desmosome protein expression regulation and localization to the desmosomal plaque, thereby maintaining cell sheet integrity and anchorage of desmosomes to intermediate filaments. Required for localization of DSG3 and YAP1 to the cell membrane in keratinocytes in response to mechanical strain, via the formation of an interaction complex composed of DSG3, YAP1, PKP1 and YWHAG. Positively regulates differentiation of keratinocytes, potentially via promoting localization of DSG1 at desmosome cell junctions. Required for calcium-independent development and maturation of desmosome plaques specifically at lateral cell-cell contacts in differentiating keratinocytes. Plays a role in the maintenance of DSG3 protein abundance, DSG3 clustering and localization of these clusters to the cell membrane in keratinocytes. May also promote keratinocyte proliferation and morphogenesis during postnatal development. Required for tight junction inside-out transepidermal barrier function of the skin. Promotes Wnt-mediated proliferation and differentiation of ameloblasts, via facilitating TJP1/ZO-1 localization to tight junctions. Binds single-stranded DNA (ssDNA), and may thereby play a role in sensing DNA damage and promoting cell survival. Positively regulates cap-dependent translation and as a result cell proliferation, via recruitment of EIF4A1 to the initiation complex and promotion of EIF4A1 ATPase activity. Regulates the mRNA stability and protein abundance of desmosome components PKP2, PKP3, DSC2 and DSP, potentially via its interaction with FXR1. |
| Protein Name | Plakophilin-1Band 6 ProteinB6p |
| Database Links | Reactome: R-HSA-351906Reactome: R-HSA-6798695Reactome: R-HSA-6805567Reactome: R-HSA-6809371 |
| Cellular Localisation | Isoform 1: Cell JunctionDesmosomeIsoform 2: NucleusNucleusCytoplasmPerinuclear RegionCell JunctionCell MembraneStress GranuleColocalizes With Eif4a1 In Stress Granules Following Arsenate Or Hydrogen Peroxide TreatmentLocalizes To Nucleoli Following Dna DamageLocated In The Cytoplasm During Early Tooth DevelopmentHowever Localizes To The Cell Membrane In Ameloblasts During Molar GrowthCa(2+)-Mediated Localization To The Cell Membrane In Dental Epithelial Cells Is Inhibited Via Wnt3aLocalizes To The Cytoplasm When The Phosphorylated Form Interacts With YwhagInitially Localized To The Cytoplasm However As Keratinocyte Differentiation Proceeds Becomes Localized To Cell Junctions As Early Cell-Cell Contacts Become Linear As Part Of Membrane SealingLocalized To Lateral Cell Contacts In Colocalization With Dsp As Epithelial Sheet Formation CompletesProtein Stability Is Increased And Localizes To The Cytoplasm When Phosphorylated At The N-Terminus By Akt2The Unphosphorylated Form Is Preferentially Localized To Desmosomes |
| Alternative Protein Names | Plakophilin-1 proteinBand 6 Protein proteinB6p proteinPKP1 protein |
Information sourced from Uniprot.org
