| Post Translational Modifications | Autophosphorylation at Ser-1070 negatively regulates the phosphatidylinositol-4,5-bisphosphate 3-kinase activity. |
| Function | Phosphoinositide-3-kinase (PI3K) phosphorylates phosphatidylinositol derivatives at position 3 of the inositol ring to produce 3-phosphoinositides. Uses ATP and PtdIns(4,5)P2 (phosphatidylinositol 4,5-bisphosphate) to generate phosphatidylinositol 3,4,5-trisphosphate (PIP3). PIP3 plays a key role by recruiting PH domain-containing proteins to the membrane, including AKT1 and PDPK1, activating signaling cascades involved in cell growth, survival, proliferation, motility and morphology. Involved in the activation of AKT1 upon stimulation by G-protein coupled receptors (GPCRs) ligands such as CXCL12, sphingosine 1-phosphate, and lysophosphatidic acid. May also act downstream receptor tyrosine kinases. Required in different signaling pathways for stable platelet adhesion and aggregation. Plays a role in platelet activation signaling triggered by GPCRs, alpha-IIb/beta-3 integrins (ITGA2B/ ITGB3) and ITAM (immunoreceptor tyrosine-based activation motif)-bearing receptors such as GP6. Regulates the strength of adhesion of ITGA2B/ ITGB3 activated receptors necessary for the cellular transmission of contractile forces. Required for platelet aggregation induced by F2 (thrombin) and thromboxane A2 (TXA2). Has a role in cell survival. May have a role in cell migration. Involved in the early stage of autophagosome formation. Modulates the intracellular level of PtdIns3P (phosphatidylinositol 3-phosphate) and activates PIK3C3 kinase activity. May act as a scaffold, independently of its lipid kinase activity to positively regulate autophagy. May have a role in insulin signaling as scaffolding protein in which the lipid kinase activity is not required. May have a kinase-independent function in regulating cell proliferation and in clathrin-mediated endocytosis. Mediator of oncogenic signal in cell lines lacking PTEN. The lipid kinase activity is necessary for its role in oncogenic transformation. Required for the growth of ERBB2 and RAS driven tumors. Has also a protein kinase activity showing autophosphorylation. |
| Protein Name | Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Beta IsoformPi3-Kinase Subunit BetaPi3k-BetaPi3kbetaPtdins-3-Kinase Subunit BetaPhosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit BetaPtdins-3-Kinase Subunit P110-BetaP110betaSerine/Threonine Protein Kinase Pik3cb |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-112399Reactome: R-HSA-114604Reactome: R-HSA-1257604Reactome: R-HSA-1660499Reactome: R-HSA-186763Reactome: R-HSA-198203Reactome: R-HSA-201556Reactome: R-HSA-202424Reactome: R-HSA-2029485Reactome: R-HSA-210993Reactome: R-HSA-2219530Reactome: R-HSA-2424491Reactome: R-HSA-2730905Reactome: R-HSA-373753Reactome: R-HSA-4420097Reactome: R-HSA-512988Reactome: R-HSA-5673001Reactome: R-HSA-6811558Reactome: R-HSA-8853659Reactome: R-HSA-9027276Reactome: R-HSA-912526Reactome: R-HSA-912631Reactome: R-HSA-9673767Reactome: R-HSA-9673770Reactome: R-HSA-9680350Reactome: R-HSA-9725370Reactome: R-HSA-9842640Reactome: R-HSA-9842663 |
| Cellular Localisation | CytoplasmNucleusInteraction With Pik3r2 Is Required For Nuclear Localization And Export |
| Alternative Protein Names | Phosphatidylinositol 4 -5-Bisphosphate 3-Kinase Catalytic Subunit Beta Isoform proteinPi3-Kinase Subunit Beta proteinPi3k-Beta proteinPi3kbeta proteinPtdins-3-Kinase Subunit Beta proteinPhosphatidylinositol 4 -5-Bisphosphate 3-Kinase 110 Kda Catalytic Subunit Beta proteinPtdins-3-Kinase Subunit P110-Beta proteinP110beta proteinSerine/Threonine Protein Kinase Pik3cb proteinPIK3CB proteinPIK3C1 protein |
Information sourced from Uniprot.org
