| Post Translational Modifications | Ubiquitinated via 'Lys-29'- and 'Lys-48'-linked ubiquitination by UBE3C, promoting its degradation. Deubiquitination by ZRANB1/TRABID promotes its stabilization, leading to autophagosome maturation. |
| Function | Catalytic subunit of the PI3K complex that mediates formation of phosphatidylinositol 3-phosphate.different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. As part of PI3KC3-C1, promotes endoplasmic reticulum membrane curvature formation prior to vesicle budding. Involved in regulation of degradative endocytic trafficking and required for the abscission step in cytokinesis, probably in the context of PI3KC3-C2. Involved in the transport of lysosomal enzyme precursors to lysosomes. Required for transport from early to late endosomes. (Microbial infection) Kinase activity is required for SARS coronavirus-2/SARS-CoV-2 replication. |
| Protein Name | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3Pi3-Kinase Type 3Pi3k Type 3Ptdins-3-Kinase Type 3Phosphatidylinositol 3-Kinase P100 SubunitPhosphoinositide-3-Kinase Class 3Hvps34 |
| Database Links | Reactome: R-HSA-109704Reactome: R-HSA-1632852Reactome: R-HSA-1660514Reactome: R-HSA-1660516Reactome: R-HSA-1660517Reactome: R-HSA-168138Reactome: R-HSA-5668599Reactome: R-HSA-9679504Reactome: R-HSA-9694676Reactome: R-HSA-9705671Reactome: R-HSA-983170 |
| Cellular Localisation | MidbodyLate EndosomeCytoplasmic VesicleAutophagosomeAs Component Of The Pi3k Complex I Localized To Pre-Autophagosome StructuresAs Component Of The Pi3k Complex Ii Localized Predominantly To EndosomesLocalizes Also To Discrete Punctae Along The Ciliary Axoneme And To The Base Of The Ciliary Axoneme |
| Alternative Protein Names | Phosphatidylinositol 3-Kinase Catalytic Subunit Type 3 proteinPi3-Kinase Type 3 proteinPi3k Type 3 proteinPtdins-3-Kinase Type 3 proteinPhosphatidylinositol 3-Kinase P100 Subunit proteinPhosphoinositide-3-Kinase Class 3 proteinHvps34 proteinPIK3C3 proteinVPS34 protein |
Information sourced from Uniprot.org
