Human PHEX protein (Recombinant) (N-His) (STJP005083)

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STJP005083
£328.50 - £1,437.50
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PHEX-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PHEX
Gene ID: 5251
Uniprot ID: PHEX_HUMAN
Immunogen Region: Ser41-Arg391
Immunogen: Homo sapiens (Human)
Function Peptidase that cleaves SIBLING (small integrin-binding ligand, N-linked glycoprotein)-derived ASARM peptides, thus regulating their biological activity. Cleaves ASARM peptides between Ser and Glu or Asp residues. Regulates osteogenic cell differentiation and bone mineralization through the cleavage of the MEPE-derived ASARM peptide. Promotes dentin mineralization and renal phosphate reabsorption by cleaving DMP1- and MEPE-derived ASARM peptides. Inhibits the cleavage of MEPE by CTSB/cathepsin B thus preventing MEPE degradation.
Protein Name Phosphate-Regulating Neutral Endopeptidase Phex
Metalloendopeptidase Homolog Pex
Vitamin D-Resistant Hypophosphatemic Rickets Protein
X-Linked Hypophosphatemia Protein
Hyp
Cellular Localisation Cell Membrane
Single-Pass Type Ii Membrane Protein
Alternative Protein Names Phosphate-Regulating Neutral Endopeptidase Phex protein
Metalloendopeptidase Homolog Pex protein
Vitamin D-Resistant Hypophosphatemic Rickets Protein protein
X-Linked Hypophosphatemia Protein protein
Hyp protein
PHEX protein
PEX protein

Information sourced from Uniprot.org

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