Human PGRMC1 protein (Recombinant) (N-His) (STJP007556)

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STJP007556
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PGRMC1-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PGRMC1
Gene ID: 10857
Uniprot ID: PGRC1_HUMAN
Immunogen Region: Pro75-Asp195
Immunogen: Homo sapiens (Human)
Post Translational Modifications O-glycosylated.contains chondroitin sulfate attached to Ser-54. Ser-54 is in the cytoplasmic domain but the glycosylated form was detected in urine, suggesting that the membrane-bound form is cleaved, allowing for production of a secreted form which is glycosylated.
Function Component of a progesterone-binding protein complex. Binds progesterone. Has many reported cellular functions (heme homeostasis, interaction with CYPs). Required for the maintenance of uterine histoarchitecture and normal female reproductive lifespan. Intracellular heme chaperone. Regulates heme synthesis via interactions with FECH and acts as a heme donor for at least some hemoproteins. Forms a ternary complex with TMEM97 receptor and low density lipid receptor/LDLR, which increases LDLR-mediated LDL lipoprotein internalization.
Protein Name Membrane-Associated Progesterone Receptor Component 1
Mpr
Dap1
Iza
Database Links Reactome: R-HSA-6798695
Cellular Localisation Microsome Membrane
Single-Pass Membrane Protein
Smooth Endoplasmic Reticulum Membrane
Mitochondrion Outer Membrane
Extracellular Side
Secreted
Localized At Cell Membrane
Probably In Lipid Rafts
In Serum-Starved Conditions
Alternative Protein Names Membrane-Associated Progesterone Receptor Component 1 protein
Mpr protein
Dap1 protein
Iza protein
PGRMC1 protein
HPR6.6 protein
PGRMC protein

Information sourced from Uniprot.org

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