| Function | E3 ubiquitin-protein ligase component of a retrotranslocation channel required for peroxisome organization by mediating export of the PEX5 receptor from peroxisomes to the cytosol, thereby promoting PEX5 recycling. The retrotranslocation channel is composed of PEX2, PEX10 and PEX12.each subunit contributing transmembrane segments that coassemble into an open channel that specifically allows the passage of PEX5 through the peroxisomal membrane. PEX2 also regulates peroxisome organization by acting as a E3 ubiquitin-protein ligase. PEX2 ubiquitinates PEX5 during its passage through the retrotranslocation channel: catalyzes monoubiquitination of PEX5 at 'Cys-11', a modification that acts as a signal for PEX5 extraction into the cytosol. Required for pexophagy in response to starvation by mediating ubiquitination of peroxisomal proteins, such as PEX5 and ABCD3/PMP70. Also involved in the response to reactive oxygen species (ROS) by mediating 'Lys-48'-linked polyubiquitination and subsequent degradation of PNPLA2/ATGL, thereby regulating lipolysis. |
| Protein Name | Peroxisome Biogenesis Factor 235 Kda Peroxisomal Membrane ProteinPeroxin-2Peroxisomal Membrane Protein 3Peroxisome Assembly Factor 1Paf-1Ring Finger Protein 72 |
| Database Links | Reactome: R-HSA-8866654Reactome: R-HSA-9033241Reactome: R-HSA-9603798 |
| Cellular Localisation | Peroxisome MembraneMulti-Pass Membrane Protein |
| Alternative Protein Names | Peroxisome Biogenesis Factor 2 protein35 Kda Peroxisomal Membrane Protein proteinPeroxin-2 proteinPeroxisomal Membrane Protein 3 proteinPeroxisome Assembly Factor 1 proteinPaf-1 proteinRing Finger Protein 72 proteinPEX2 proteinPAF1 proteinPMP3 proteinPMP35 proteinPXMP3 proteinRNF72 protein |
Information sourced from Uniprot.org
