Human Peroxiredoxin 1/PRDX1 protein (Recombinant) (His-Tag) (STJP019740)

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STJP019740
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE/Enzyme Activity
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human Peroxiredoxin 1/PRDX1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in 20mM Tris-HCl buffer (pH 7.5) containing 20% Glycerol
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Immunoreactivity: Specific activity is >2, 000pmol/min/ug. Enzymatic activity is defined as the amount of hydroperoxide that 1ug of enzyme can reduce at 25C for minute.
Gene Symbol: PRDX1
Gene ID: 5052
Uniprot ID: PRDX1_HUMAN
Immunogen Region: 1-199aa
Accession Number: NP_002565.1
Immunogen: Human
Immunogen Sequence: MSSGNAKIGH PAPNFKATAV MPDGQFKDIS LSDYKGKYVV FFFYPLDFTF VCPTEIIAFS DRAEEFKKLN CQVIGASVDS HFCHLAWVNT PKKQGGLGPM NIPLVSDPKR TIAQDYGVLK ADEGISFRGL FIIDDKGILR QITVNDLPVG RSVDETLRLV QAFQFTDKHG EVCPAGWKPG SDTIKPDVQK SKEYFSKQK
Post Translational Modifications Phosphorylated on Thr-90 during the M-phase, which leads to a more than 80% decrease in enzymatic activity. Acetylation increases reducing activity and resistance to superoxidation. Deacetylated by HDAC6 which decreases reducing activity. The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) instead of its condensation to a disulfide bond. It can be reactivated by forming a transient disulfide bond with sulfiredoxin SRXN1, which reduces the cysteine sulfinic acid in an ATP- and Mg-dependent manner.
Function Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Might participate in the signaling cascades of growth factors and tumor necrosis factor-alpha by regulating the intracellular concentrations of H(2)O(2). Reduces an intramolecular disulfide bond in GDPD5 that gates the ability to GDPD5 to drive postmitotic motor neuron differentiation.
Protein Name Peroxiredoxin-1
Natural Killer Cell-Enhancing Factor A
Nkef-A
Proliferation-Associated Gene Protein
Pag
Thioredoxin Peroxidase 2
Thioredoxin-Dependent Peroxide Reductase 2
Thioredoxin-Dependent Peroxiredoxin 1
Database Links Reactome: R-HSA-3299685
Reactome: R-HSA-5628897
Reactome: R-HSA-8862803
Reactome: R-HSA-9818027
Cellular Localisation Cytoplasm
Melanosome
Identified By Mass Spectrometry In Melanosome Fractions From Stage I To Stage Iv
Alternative Protein Names Peroxiredoxin-1 protein
Natural Killer Cell-Enhancing Factor A protein
Nkef-A protein
Proliferation-Associated Gene Protein protein
Pag protein
Thioredoxin Peroxidase 2 protein
Thioredoxin-Dependent Peroxide Reductase 2 protein
Thioredoxin-Dependent Peroxiredoxin 1 protein
PRDX1 protein
PAGA protein
PAGB protein
TDPX2 protein

Information sourced from Uniprot.org

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