Human PENK protein (Recombinant) (N-His) (STJP003530)

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STJP003530
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PENK-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PENK
Gene ID: 5179
Uniprot ID: PENK_HUMAN
Immunogen Region: Glu25-Ala133
Immunogen: Homo sapiens (Human)
Function Met-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Leu-enkephalin: Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress. Met-enkephalin-Arg-Phe: Met-enkephalin-Arg-Phe neuropeptide acts as a strong ligand of Mu-type opioid receptor OPRM1. Met-enkephalin-Arg-Phe-binding to OPRM1 in the nucleus accumbens of the brain increases activation of OPRM1, leading to long-term synaptic depression of glutamate release. PENK(114-133): Increases glutamate release in the striatum and decreases GABA concentration in the striatum. PENK(237-258): Increases glutamate release in the striatum.
Protein Name Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin
Opioid Growth Factor
Ogf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe
Database Links Reactome: R-HSA-375276
Reactome: R-HSA-381426
Reactome: R-HSA-418594
Reactome: R-HSA-8957275
Cellular Localisation Cytoplasmic Vesicle
Secretory Vesicle
Chromaffin Granule Lumen
Secreted
Alternative Protein Names Proenkephalin-A Cleaved Into - Synenkephalin - Met-Enkephalin protein
Opioid Growth Factor protein
Ogf - Penk(114-133 - Penk(143-183 - Met-Enkephalin-Arg-Gly-Leu - Leu-Enkephalin - Penk(237-258 - Met-Enkephalin-Arg-Phe protein
PENK protein

Information sourced from Uniprot.org

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