Human PEDF/SERPINF1 protein (Recombinant) (His-Tag) (STJP016485)

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STJP016485
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Short Description :Recombinant-Human PEDF/SERPINF1-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Applications:SDS-PAGE
Host:E.coli
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Concentration:0.5 mg/mL
Formulation:Liquid in 20mM Tris-HCl buffer (pH 8.0) containing 20% Glycerol
Storage Instruction:For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol:SERPINF1
Gene ID:5176
Uniprot ID:PEDF_HUMAN
Accession Number:NP_002606.3
Immunogen:Human
Immunogen Region:20-418aa
Immunogen Sequence:MGSSHHHHHH SSGLVPRGSH MQNPASPPEE GSPDPDSTGA LVEEEDPFFK VPVNKLAAAV SNFGYDLYRV RSSMSPTTNV LLSPLSVATA LSALSLGAEQ RTESIIHRAL YYDLISSPDI HGTYKELLDT VTAPQKNLKS ASRIVFEKKL RIKSSFVAPL EKSYGTRPRV LTGNPRLDLQ EINNWVQAQM KGKLARSTKE IPDEISILLL GVAHFKGQWV TKFDSRKT
Tissue Specificity Retinal pigment epithelial cells and blood plasma.
Post Translational Modifications The N-terminus is blocked. Extracellular phosphorylation enhances antiangiogenic activity. N- and O-glycosylated. O-glycosylated with a core 1 or possibly core 8 glycan.
Function Neurotrophic protein.induces extensive neuronal differentiation in retinoblastoma cells. Potent inhibitor of angiogenesis. As it does not undergo the S (stressed) to R (relaxed) conformational transition characteristic of active serpins, it exhibits no serine protease inhibitory activity.
Protein Name Pigment Epithelium-Derived Factor
Pedf
Cell Proliferation-Inducing Gene 35 Protein
Epc-1
Serpin F1
Database Links
Cellular Localisation Secreted
Melanosome
Enriched In Stage I Melanosomes
Alternative Protein Names Pigment Epithelium-Derived Factor protein
Pedf protein
Cell Proliferation-Inducing Gene 35 Protein protein
Epc-1 protein
Serpin F1 protein
SERPINF1 protein
PEDF protein
PIG35 protein

Information sourced from Uniprot.org

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