| Function | Kinase that plays a key role in the regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism. Mediates cellular responses to insulin. Plays an important role in maintaining normal blood glucose levels and in metabolic adaptation to nutrient availability. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. Plays a role in the regulation of cell proliferation and in resistance to apoptosis under oxidative stress. Plays a role in p53/TP53-mediated apoptosis. |
| Protein Name | Pyruvate DehydrogenaseAcetyl-Transferring Kinase Isozyme 2 - MitochondrialPyruvate Dehydrogenase Kinase Isoform 2Pdh Kinase 2Pdkii |
| Database Links | Reactome: R-HSA-204174Reactome: R-HSA-5362517 |
| Cellular Localisation | Mitochondrion Matrix |
| Alternative Protein Names | Pyruvate Dehydrogenase proteinAcetyl-Transferring Kinase Isozyme 2 - Mitochondrial proteinPyruvate Dehydrogenase Kinase Isoform 2 proteinPdh Kinase 2 proteinPdkii proteinPDK2 proteinPDHK2 protein |
Information sourced from Uniprot.org
