| Host: |
Pichia |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Recombinant-Human PDGF-BB-No-tag protein was developed from pichia and has a target region of No-tag. For use in research applications. |
| Formulation: |
Lyophilized from a 0.22 Mu m filtered solution of 20mM NaAc, pH 4.5. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Immunoreactivity: |
Measured by its binding ability in a functional ELISA.Immobilized PDGF-BB (Catalog: RP01763) at 2 Mu g/mL (100 Mu L/well) can bind Human PDGFRB (Catalog: RP00126) with a linear range of 0.1-104.7 ng/mL. |
| Gene Symbol: |
PDGFB |
| Gene ID: |
5155 |
| Uniprot ID: |
PDGFB_HUMAN |
| Immunogen Region: |
Ser82-Thr190 |
| Immunogen: |
Recombinant Human PDGF-BB Protein is produced by Pichia expression system. The target protein is expressed with sequence (Ser82-Thr190) of human PDGF-BB (Accession #NP_002599.1) fused with a additional amino acid free. |
| Function | Growth factor that plays an essential role in the regulation of embryonic development, cell proliferation, cell migration, survival and chemotaxis. Potent mitogen for cells of mesenchymal origin. Required for normal proliferation and recruitment of pericytes and vascular smooth muscle cells in the central nervous system, skin, lung, heart and placenta. Required for normal blood vessel development, and for normal development of kidney glomeruli. Plays an important role in wound healing. Signaling is modulated by the formation of heterodimers with PDGFA. |
| Protein Name | Platelet-Derived Growth Factor Subunit BPdgf Subunit BPdgf-2Platelet-Derived Growth Factor B ChainPlatelet-Derived Growth Factor Beta PolypeptideProto-Oncogene C-SisBecaplermin |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-1257604Reactome: R-HSA-186763Reactome: R-HSA-186797Reactome: R-HSA-2219530Reactome: R-HSA-3000171Reactome: R-HSA-5673001Reactome: R-HSA-6811558 |
| Cellular Localisation | SecretedReleased By Platelets Upon Wounding |
| Alternative Protein Names | Platelet-Derived Growth Factor Subunit B proteinPdgf Subunit B proteinPdgf-2 proteinPlatelet-Derived Growth Factor B Chain proteinPlatelet-Derived Growth Factor Beta Polypeptide proteinProto-Oncogene C-Sis proteinBecaplermin proteinPDGFB proteinPDGF2 proteinSIS protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
