| Host: | E.coli |
| Applications: | ELISA/Immunogen/SDS-PAGE/WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Recombinant-Human PDE5A-N-His protein was developed from e.coli and has a target region of N-His. For use in research applications. |
| Formulation: | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Dilution Range: | Reconstitute in sterile water for a stock solution. A copy of datasheet will be provided with the products, please refer to it for details. |
| Storage Instruction: | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
| Gene Symbol: | PDE5A |
| Gene ID: | 8654 |
| Uniprot ID: | PDE5A_HUMAN |
| Immunogen Region: | Glu321-Lys482 |
| Immunogen: | Homo sapiens (Human) |
| Post Translational Modifications | Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
| Protein Name | Cgmp-Specific 3' -5'-Cyclic PhosphodiesteraseCgmp-Binding Cgmp-Specific PhosphodiesteraseCgb-Pde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-445355Reactome: R-HSA-9013422 |
| Cellular Localisation | |
| Alternative Protein Names | Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase proteinCgmp-Binding Cgmp-Specific Phosphodiesterase proteinCgb-Pde proteinPDE5A proteinPDE5 protein |
Information sourced from Uniprot.org