Human PDE5A protein (Recombinant) (N-His) (STJP003402)

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STJP003402
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PDE5A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PDE5A
Gene ID: 8654
Uniprot ID: PDE5A_HUMAN
Immunogen Region: Glu321-Lys482
Immunogen: Homo sapiens (Human)
Post Translational Modifications Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation.
Function Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP.
Protein Name Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase
Cgmp-Binding Cgmp-Specific Phosphodiesterase
Cgb-Pde
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-445355
Reactome: R-HSA-9013422
Alternative Protein Names Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase protein
Cgmp-Binding Cgmp-Specific Phosphodiesterase protein
Cgb-Pde protein
PDE5A protein
PDE5 protein

Information sourced from Uniprot.org

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