Human PDE2A protein (Recombinant) (N-His) (STJP008793)

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STJP008793
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PDE2A-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PDE2A
Gene ID: 5138
Uniprot ID: PDE2A_HUMAN
Immunogen Region: Asp241-Gln387
Immunogen: Homo sapiens (Human)
Function cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Protein Name Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase
Cyclic Gmp-Stimulated Phosphodiesterase
Cgs-Pde
Cgspde
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Isoform Pde2a3: Cell Membrane
Lipid-Anchor
Isoform Pde2a2: Mitochondrion Matrix
Mitochondrion Inner Membrane
Mitochondrion Outer Membrane
Isoform Pde2a1: Cytoplasm
Isoform 5: Mitochondrion
Alternative Protein Names Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase protein
Cyclic Gmp-Stimulated Phosphodiesterase protein
Cgs-Pde protein
Cgspde protein
PDE2A protein

Information sourced from Uniprot.org

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