Human PDCD4/PD4 protein (Recombinant) (N-His) (STJP007323)

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STJP007323
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Human PDCD4/PD4-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: PDCD4
Gene ID: 27250
Uniprot ID: PDCD4_HUMAN
Immunogen Region: Phe164-Tyr469
Immunogen: Homo sapiens (Human)
Post Translational Modifications Polyubiquitinated, leading to its proteasomal degradation. Rapidly degraded in response to mitogens. Phosphorylation of the phosphodegron promotes interaction with BTRC and proteasomal degradation. Phosphorylated at Ser-67 by RPS6KB1 in response to mitogens.phosphorylation promotes proteasomal degradation of PDCD4.
Function Inhibits translation initiation and cap-dependent translation. May excert its function by hindering the interaction between EIF4A1 and EIF4G. Inhibits the helicase activity of EIF4A. Modulates the activation of JUN kinase. Down-regulates the expression of MAP4K1, thus inhibiting events important in driving invasion, namely, MAPK85 activation and consequent JUN-dependent transcription. May play a role in apoptosis. Tumor suppressor. Inhibits tumor promoter-induced neoplastic transformation. Binds RNA.
Protein Name Programmed Cell Death Protein 4
Neoplastic Transformation Inhibitor Protein
Nuclear Antigen H731-Like
Protein 197/15a
Database Links Reactome: R-HSA-8950505
Cellular Localisation Nucleus
Cytoplasm
Shuttles Between The Nucleus And Cytoplasm
Predominantly Nuclear Under Normal Growth Conditions
And When Phosphorylated At Ser-457
Alternative Protein Names Programmed Cell Death Protein 4 protein
Neoplastic Transformation Inhibitor Protein protein
Nuclear Antigen H731-Like protein
Protein 197/15a protein
PDCD4 protein
H731 protein

Information sourced from Uniprot.org

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